Prefect: H.E. Cardinal José Tolentino de Mendonça

Secretary: Bishop Paul Desmond Tighe, titular Bishop of Drivastrum (Culture Section)

Secretary: Rev. Msgr. Giovanni Cesare Pagazzi (Education Section)

Under-Secretary: Msgr. Melchor José Sánchez de Toca y Alameda

Under-Secretary: Prof. Antonella Sciarrone Alibrandi

Adjunct Under-Secretary: Msgr. Carlo Maria Polvani