Prefect: H.E. Cardinal José Tolentino de Mendonça
Secretary: Bishop Paul Desmond Tighe, titular Bishop of Drivastrum (Culture Section)
Secretary: Rev. Msgr. Giovanni Cesare Pagazzi (Education Section)
Under-Secretary: Msgr. Melchor José Sánchez de Toca y Alameda
Under-Secretary: Prof. Antonella Sciarrone Alibrandi
Adjunct Under-Secretary: Msgr. Carlo Maria Polvani