Prefect: H.E. Cardinal José Tolentino de Mendonça

Secretary: Bishop Paul Desmond Tighe, titular Bishop of Drivastrum (Culture Section)

Secretary: Rev. Msgr. Giovanni Cesare Pagazzi (Education Section)

Under-Secretary: Prof. Antonella Sciarrone Alibrandi

Under-Secretary: Father Antonino Spadaro, S.J. 

Under-Secretary: Msgr. Matthias Ambros
 

Adjunct Under-Secretary: Msgr. Carlo Maria Polvani